A structural analysis of the regulatory domain from the cGMP-dependent protein kinase Iα
نویسندگان
چکیده
Background The cGMP-dependent protein kinase (PKG) has two tandem cyclic nucleotide binding (CNB) domains which act as the primary intracellular receptor for cGMP [1,2]. PKG exhibits a homodimeric rod-like structure which undergoes significant molecular rearrangements upon the binding of cGMP [3-5]. However, a detailed structural analysis of the core regulatory elements inherent to PKG is still required.
منابع مشابه
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2011